OR11-005 - Mast cells respond to pathogen signals with IL-1ß
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چکیده
منابع مشابه
OR11-005 - Mast cells respond to pathogen signals with IL-1ß
Introduction Mast cells, key effector cells of allergic and innate immune responses, have recently been reported to be an important source of IL-1ß in patients with autoinflammatory conditions such as cryopyrin-associated-periodic-fever syndromes (CAPS). CAPS patients show IL-1beta-driven systemic inflammation together with non-histamine dependent urticarial rash, which are caused by activating...
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Mast cells have been attributed several functions in both health and disease. Mast cell activation and release of inflammatory mediators are associated with the pathogenesis of several diseases, in particular that of allergic diseases. While the notion of mast cells as important, protective sentinel cells is old, this feature of the cell is not well recognized outside the mast cell field. The m...
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The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-Fc RI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function are poorly understood. We found that IL-33, but not IL-1 or IL-18, induced IL-13 and...
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In addition to their role in allergic disease, mast cells can respond to many pathogens through the production of proinflammatory mediators. Mast cells are located close to blood vessels and sites of pathogen exposure. T and NK cells must reach sites of infection to eliminate affected cells, however possible mechanisms mediating this migration are poorly understood. We hypothesized that human m...
متن کاملImpact of IL -9 and IL-33 in mast cells.
Cytokines serve as chemical communicators from one cell to another and most of them have pro-inflammatory activity. Mast cells have been recognised as important mediators of the pathogenesis of allergy and inflammation, suggesting a role for IL-33-mediated mast cell activation. IL-33 was recently identified as a ligand for the orphan IL-1 family receptor T1/ST2 and is mainly expressed by mast c...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2013
ISSN: 1546-0096
DOI: 10.1186/1546-0096-11-s1-a194